Terpenes for Pain Relief: A Natural Solution for Optimal Comfort


In the pursuit of pain relief, many individuals seek alternative remedies that can provide a natural and holistic approach. Terpenes, the aromatic compounds found in various plants, have gained significant attention for their potential therapeutic benefits. In this blog post, we will explore the fascinating world of terpenes and delve into how they can be harnessed to alleviate pain effectively. A number of studies have shown that terpenes can produce pain relief in various pain states in both humans and animals (Schwarz et al 2023). 

Understanding Terpenes

Terpenes are organic compounds that contribute to the aroma and flavor of plants. They are found in abundance in essential oils extracted from plants such as lavender, eucalyptus, and citrus fruits. These aromatic compounds have been utilized for centuries in traditional medicine due to their potential health-promoting properties.

The Relationship Between Terpenes and Pain Relief

Several studies have suggested that terpenes possess analgesic properties, making them a promising option for pain management. Terpenes interact with various receptors and neurotransmitters in the body, influencing the perception of pain and inflammation. Additionally, certain terpenes have shown anti-inflammatory effects, further contributing to their potential pain-relieving properties. Researchers found that Cannabis terpenes, when used by themselves, mimic the effects of cannabinoids, including a reduction in pain sensation. When combined with cannabinoids, the pain-relieving effects were amplified without an increase in negative side effects (Shagoury 2021)..

Prominent Terpenes for Pain Relief

Limonene: Found in citrus fruits like lemons and oranges, limonene has demonstrated anti-inflammatory and analgesic properties. It may aid in reducing pain associated with conditions like arthritis and neuropathy.

Linalool: This terpene, commonly found in lavender and other floral plants, has a calming effect on the body and mind. It may assist in alleviating pain caused by tension, stress, or headaches.

Beta-Caryophyllene: Present in black pepper, cloves, and various herbs, beta-caryophyllene has shown potential anti-inflammatory and analgesic effects. It interacts with the body’s endocannabinoid system, offering pain relief similar to cannabinoids like CBD.

Pinene: Abundant in pine trees and herbs like rosemary, pinene possesses anti-inflammatory properties that may help in managing pain caused by conditions such as osteoarthritis.

Utilizing Terpenes for Pain Relief

There are several ways to harness the potential benefits of terpenes for pain relief

Aromatherapy: Diffusing essential oils rich in terpenes, such as lavender or citrus, can create a soothing environment and help alleviate pain.

Topical Application: Applying terpene-infused creams, balms, or oils directly to the affected area can provide targeted relief from localized pain.

Herbal Supplements: Certain herbal supplements combine terpenes with other natural compounds to create synergistic effects, enhancing their pain-relieving potential.

Cannabis-Based Products: Cannabis contains a wide range of terpenes, and products such as CBD oil or full-spectrum hemp extracts may offer pain relief due to the combined effects of terpenes and cannabinoids.

Studies of Cannabis for Neuropathic Pain: A number of studies have evaluated cannabis for treating neuropathic pain. Overall, available data support the efficacy of smoked or inhaled cannabis in its flower form when used as monotherapy or adjunctive therapy for relief of neuropathic pain of various etiologies. Many studies also report secondary benefits, including better sleep and functional improvement (Modesto-Lowe et al 2018). 


Terpenes, with their diverse range of aromatic compounds, hold promise as natural alternatives for pain relief. Their analgesic and anti-inflammatory properties make them an intriguing option for those seeking a holistic approach to managing pain. Whether through aromatherapy, topical application, herbal supplements, or cannabis-based products, exploring the potential benefits of terpenes may help individuals find relief from discomfort and enhance their overall well-being.

Disclaimer: It is essential to consult with a healthcare professional before incorporating terpenes or any new pain management regimen, especially if you have pre-existing medical conditions or are currently taking medication.

Remember, each individual’s experience may vary, and further research is necessary to fully understand the effects of terpenes on pain relief.

References & Citations

Schwarz, A. M., Keresztes, A., Bui, T., Hecksel, R. J., Peña, A., Lent, B., Gao, Z. G., Gamez-Rivera, M., Seekins, C. A., Chou, K., Appel, T. L., Jacobson, K. A., Al-Obeidi, F. A., & Streicher, J. M.

March 29, 2023

Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A 2A Receptors.


Katherine Shagoury

August 24, 2021

Study shows cannabis terpenes provide pain relief


Vania Modesto-Lowe, MD, MPH, Rachel Bojka, MS, PA-C and Camille Alvarado, DO, MPH, Cleveland Clinic Journal of Medicine

December 2018

Cannabis for peripheral neuropathy: The good, the bad, and the unknown